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Matthew Hyzy, DO

Jason Markle, DO

About Dr. Hyzy


Doctor Hyzy is Board Certified and fellowship trained in Interventional Orthopedics. He is published in the use of Autologous Orthobiologics including platelet derived growth factors and mesenchymal stem cells for orthopedic and spinal conditions. Dr. Hyzy is a Chicago native but moved to Florida in his youth and started his pursuit of medical training. Dr. Hyzy completed residency training at The University of Texas at Austin Dell Medical School in Physical Medicine and Rehabilitation (P.M.R./Physiatry). There, he served as Chief resident and garnered numerous clinical experiences in Physiatry, Surgical and Non-Surgical Orthopedics, Neurosurgery, Interventional Physiatry, Pain Management, Interventional Spine and Regenerative Medicine; which fueled his desire to pursue more training in Interventional Orthopedics and Regenerative Medicine. He was subsequently honored to be chosen as a fellow in Interventional Orthopedics at The Centeno Schultz Clinic.

Dr. Hyzy’s previous role as a personal fitness instructor, an Osteopathic Physician, and a Physiatrist have all aligned in a holistic approach to the treatment of patients with pain, impairments, and dysfunction. He uses these experiences to optimize function and decrease pain with biomechanical evaluation, procedural interventions including diagnostic/interventional ultrasound and fluoroscopically guided procedures. Dr. Hyzy continues to promote the field in patient outcomes and research as well as providing clinical training for other physicians while serving as a clinical instructor for the Interventional Orthopedics Foundation. Dr Hyzy has served on numerous organized medicine associations, provided medical coverage for the annual Austin Marathon and provided pre-participation athletic physicals as a resident physician.

Dr. Hyzy is proud to be an attending physician at The Centeno-Schultz Clinic where he is an integral part of the Interventional Orthopedics fellowship and the progression of regenerative medicine research. His research interests include the use of Orthobiologics (Platelet Rich Plasma, Platelet Lysate, and Mesenchymal Stem Cells) in musculoskeletal medicine, Osteoarthritis, percutaneous ACL repair, axial spinal disorders while participating in new treatment strategies to assist patients.

Outside of Medicine, his interests include exploring the Rocky Mountain active lifestyle, paddle boarding, Mtn. Biking, Yoga, international cuisine and spending time with his family and friends.



July 1, 2017 – Current
The Centeno-Schultz Clinic
Interventional Orthopedics
Center for Regenerative Medicine

Medical Training

Fellowship: The Centeno – Schultz Clinic
Interventional Orthopedics
Regenerative Medicine
403 Summit Blvd. Ste. 201
Broomfield, CO 80021
July 2016 – June 30 2017
More than 1500 regenerative medicine, spine, and interventional orthopedic procedures performed

Resident Physician; Physical Medicine and Rehabilitation
University of Texas at Austin; Dell Medical School
Chief Resident 2015-2016
M.D. Anderson Cancer Center, Houston, Texas
Seton Brain and Spine Institute;
Neurosurgery and Neurosurgical Oncology, Austin, Texas
Central Texas Rehabilitation Hospital, Austin, Texas
Texas Orthopedics, Austin, Texas
Center for Healing and Regenerative Medicine, Austin, Texas
July 1, 2013-June 30. 2016

Osteopathic Traditional Rotating Internship
Broward Health Medical Center, Ft. Lauderdale, FL
NOVA Southeastern University College of Osteopathic Medicine
July 1, 2012-June 30, 2013
Clinical training in Internal Medicine, Family Medicine, Obstetrics and Gynecology, Pediatrics, Cardiology, Pulmonary/Critical Care, Emergency Medicine, General surgery, Pain Medicine, Interventional Spine, Orthopedics, Neurosurgery and surgical subspecialties.
Proficient in Osteopathic Manual Medicine.


Lake Erie College of Osteopathic Medicine, Bradenton, FL
Doctorate of Osteopathic Medicine

July 2008-June 2012

Florida State University, Tallahassee, FL
College of Human Sciences

May-Aug. 2007: MCB 5408; HUN 5930

The University of West Florida, Pensacola, FL
Bachelors of Science; Biology
Certificate of Qualification in Physiology
U.W.F. Honors Program

Aug. 2002-Dec.2006

Lawton Chiles High School, Tallahassee, FL
Class of 2002


A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up
Published December 13 2018.

Interventional Orthopedics in Pain Medicine practice.
Techniques in regional Anesthesia and Pain Management. Nov. 2016.

Bone marrow derived stem cells and their application in Pain medicine.
Submitted for publication. 2016.

Anterior Cruciate Ligament Tears Treated with Imaging Guided Percutaneous Injection of Autologous Bone Marrow Concentrate: An Expanded Case Series.
Published 2017.

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells.
Published 2017.

A prospective multi-site registry data study of treatment for lower back pain with radicular pain using epidural injection of platelet lysate.
Published 2017.

How Interventional Orthopedics Will be the Next Interventional Cardiology.
Submitted for publication. 2017.

Orthopedics today. Point /counter point on ACL injuries.
Submitted for publication. 2017.

Research Experience

2017: Preventable Morbidity and Mortality in Bone Marrow Concentrate Injections for Knee Osteoarthritis Compared to Total Knee Arthroplasty
2017: Randomized Controlled Trial R.C.T. Comparing Autologous Bone Marrow Concentrate to exercise for Knee Osteoarthritis.
2016-current: R.C.T. for acute Anterior Cruciate Ligament A.C.L. tears treated with Autologous bone marrow concentrate.
2016-current: RCT for supraspinatus tears treated with Autologous bone marrow concentrate.
2016-current: Orthobiologic use for Neuro-Musculoskeletal disease.
2016: Programmatic development of residency Ultrasound and sports medicine curriculum
2016: Dorsal Root Rhizotomy for Spasticity
2015: Prehabilitation for Cardiac Transplant in Beckers Muscular Dystrophy:
2015-current: UT Austin mechanical engineering rehabilitation research collaborative on neurological injury
2015-current. Quality Improvement: Improving communication with outpatient physician for I.P.R.
2014-current. Quality Improvement: C.V.A. and Acute Transfer from Inpatient Rehab back to Hospital.
2013: Rehabilitation of Pediatric epilepsy after cortical resection
2011-2013. Treatment and Rehabilitation of Supracondylar Periprosthetic Femoral Fractures with the Megaprosthesis
2006: T.M.A.O. Infusion and Loss of Equilibrium in Lagodon rhomboids


June 2017: Orthobiologics for spinal disorders; INTRADISCAL PRP AND STEM CELLS
April 2016: Rehabilitation of the Neurogenic Shoulder
Jan. 2016: Ultrasound of the Knee and Shoulder
July 2015: Musculoskeletal examination.
Oct. 2014: Clinical Research in Physiatry
Sep. 2014: Anterior Knee Pain
Aug 2014: Pulmonary Rehabilitation
July 2014: Charcot Arthropathy
July 2014: Cerebrovascular Disease
June 2014: Hyponatremia in S.C.I.
May 2014: Complex Regional Pain Syndrome
Mar. 2014: Rheumatoid and Inflammatory Arthropathies
Nov. 2013: Hyperkinetic Movement Disorders
Oct. 2013: Paroxysmal Autonomic Instability and Dystonia
May 2013: Poster; Treatment and Rehabilitation of Supracondylar Periprosthetic Femoral Fractures with the Megaprosthesis
March 2013: Ocular Manifestations of Infectious Disease.
Sep. 2012: Pediatric Respiratory Infections
April 2012: The Approach to Thermal Injury
Nov. 2011: Electrical Stimulation in the Nonunion.
April 2011: Common Peroneal Neuropathy after Valgus Knee Arthroplasty
March 2011: Bisphosphonate Treatment and Incidence of Femur Fractures
Journal Club Presentations monthly during residency
Aug 2007: Meta-analysis on Metabolic Syndrome

Board Certifications:

Diplomate: American Board of Physical Medicine and Rehabilitation

Awards and Scholarships

Oct. 2014: Texas Pain Society P.M.R. Scholarship
June 2012: Florida Osteopathic Medical Association
Outstanding Student Leadership Award
2011 and 2010 LECOM General Scholarship
2010 LECOM Student D.O. of the Year nominee
2010 A.O.A. T.O.U.C.H. award
2004 recipient: Dr. Charles A. Preuss Medical Award
2002 recipient: The University of West Florida; John C. Pace Jr. Scholar Award for Leadership and Academic Excellence

Membership and Leadership

Interventional Orthopedics Foundation
2009-2010: Florida Osteopathic Medical Association Student District Society President
Association of Academic Physiatrists
American Academy of Physical Medicine and Rehabilitation
American Osteopathic College of Physical Medicine and Rehabilitation
Texas Pain Society
Texas Osteopathic Medical Association
Texas Medical Association
Austin Physical Medicine and Rehabilitation Society
Travis County Medical Society
Florida Osteopathic Medical Association
Florida Society of P.M.R.
Florida Academy of Pain Medicine

Community Service

May 2014, April-May 2015: Austin Independent School District Athletic Physicals
February 2014: Austin Marathon
Summer 2009: Medical Mission; Treasure beach, Jamaica
Aug 2003-April 2010: Florida Sheriff Youth Ranch
Big Brother; Big Brothers and Big Sisters of the Big Bend.
Relay For Life, Helping Hands Mission, Habitat for Humanity,
Loaves and Fishes, American Heart Walk, Best Buddies.

Regenerative Orthopedic Doctor, Dr. Hyzy

Request an Appointment with Dr. Hyzy

Insurance may cover office visits, consultations, diagnostic testing, examinations and bracing. However, most insurance does not currently cover Regenexx Procedures at this time.