Skip to Main Content
Make an Appointment

EDS Back Pain

Ehlers-Danlos Syndrome Back Pain

Low back pain is common throughout the United States with an incidence of 1.39 per 1000 person-years.(1). It accounts for 3.15 of all emergency visits.  It is also problematic in patients with Ehler-Danlos Syndrome (EDS). EDS back pain is truly a debilitating issue that could use some light shed upon it.

What is Ehler-Danlos Syndrome

Collagen triple helix

A group of inherited disorders that affect and weaken the connective tissues such as tendons and ligaments (2).  Primary sites of involvement include skin, joint, and blood vessels. Joints are typically hypermobile with excessive joint range of motion as a result of a defect in collagen formation.

Is Ehlers Danlos painful? Yes!

Overall, approximately 90% or more EDS patients suffer from chronic pain (3).  Common sources of pain include tissue trauma, myofascial, joint, and nerve-related pain (4). Hypermobile joints are unstable and susceptible to sprain, dislocation, subluxation, and hyperextension which can cause muscle, tendon, ligament, and joint injury and pain.

Does hypermobility affect the spine?

The lumbar spine is comprised of 5 intervertebral bodies and discs.  The lumbar spine is stabilized by supporting muscles, tendons, and ligaments.  The supra, interspinous ligaments, and thoracolumbar fascia in the low back are critical stabilizers and can be affected in patients with EDDS.  Laxity of the supporting ligaments and fascia can result in injury to the disc, facets, and lumbar nerves.

The sacroiliac joint can also be a source of low back pain.

What is the SI joint?

The sacroiliac joint is a critical joint in the low back formed by the ilium and sacrum bones.  The ilium is the bone that you put your hand on when scolding someone.  The SI joint has cartilage between the two boney surfaces and functions as a shock absorber.  The stability of the SI joint is dependent in part upon the extensive ligaments.  Major SI joint ligaments include the iliolumbar, sacrospinous, sacrotuberous, and long and short dorsal ligaments.

Injury or instability of the supporting ligaments and or the  SI joint can result in significant lower back and or leg pain.  EDS patients are particularly susceptible to Si joint pain as a result of their hypermobile, lax ligaments. Common Si joint referral patterns are demonstrated below.in brown.

Ehlers Danlos back pain

Treatment Options for SI joint 

The goal of treatment is to create stability, decrease inflammation in the joint, and repair any cartilage damage.  Options include bracing which will stabilize the joint.  Physical therapy is important as it provides the strengthening of supporting muscles and improvement in SI joint stability. Steroid Injections have been a longstanding standard of care.  Unfortunately, steroids compromise ligamental strength and integrity(5).  For EDS patients this is problematic as their ligaments are more often than not already loose due to the defect in collagen formation.

Is There an Alternative to Steroid Injections?

Yes!!   Platelet-rich plasma injected into the SI joint under ultrasound guidance has been demonstrated to be a better treatment option than steroids in a recent study. (6). The efficacy of the steroid injection was reduced to only 25% at 3 months whereas the PRP group at the same time interval had a 90% benefit.   Another study demonstrated PRP as an effective treatment option in patients with SI joint dysfunction with marked improvement in stability, improved quality of life, and a significant reduction in pain (7).

At the Centeno-Schultz Clinic, we have extensive experience in the management of treatment of patients with EDS.  High-dose steroid injections have no role in our practice, especially in patients with hypermobility or EDS.  All injections are performed with either ultrasound or x-ray to ensure accurate placement of the platelets and bone marrow concentrate (containing stem cells).  We have a state-of-the-art lab that allows us to concentrate both platelets and bone marrow concentrate, or “BMC” for short, to the concentration of stem cells that is required for your specific condition.  BMC is another option for those EDS with significant instability who have not responded to platelet therapy.

Ehler-Danlos syndrome has multiple clinical presentations one of which is low back pain.  This can involve the SI joint due to ligamental instability.  High dose steroids can compromise the ligaments whereby further compromising the stability of the SI joint.  If you or a loved one has EDS back pain please consider a new patient evaluation at the Centeno-Schultz Clinic where we will review your treatment options which may include either platelets or bone marrow BMC or both.

Doctors at Centeno-Schultz Clinic that Treat Back Pain from Ehlers-Danlos Syndrome

Christopher J. Centeno, MD

Christopher J. Centeno, M.D. is an international expert and specialist in Interventional Orthopedics and the clinical use of bone marrow concentrate in orthopedics. He is board-certified in physical medicine and rehabilitation with a subspecialty of pain medicine through The American Board of Physical Medicine and Rehabilitation. Dr. Centeno is one of the few physicians in the world with extensive experience in the culture expansion of and clinical use of adult bone marrow concentrate to treat orthopedic injuries. His clinic incorporates a variety of revolutionary pain management techniques to bring its broad patient base relief and results. Dr. Centeno treats patients from all over the US who…

Read more

John Schultz, MD

My passion and specialization are in the evaluation and treatment of cervical disc, facet, ligament and nerve pain, including the non-surgical treatment of Craniocervical instability (CCI). I quit a successful career in anesthesia and traditional pain management to pursue and advance the use of PRP and bone marrow concentrate for common orthopedic conditions. I have been a patient with severe pain and know firsthand the limitations of traditional orthopedic surgery. I am a co-founder of the Centeno-Schultz Clinic which was established in 2005. Being active is a central part of my life as I enjoy time skiing, biking, hiking, sailing with my family and 9 grandchildren.

Read more

John Pitts, M.D.

Dr. Pitts is originally from Chicago, IL but is a medical graduate of Vanderbilt School of Medicine in Nashville, TN. After Vanderbilt, he completed a residency in Physical Medicine and Rehabilitation (PM&R) at Emory University in Atlanta, GA. The focus of PM&R is the restoration of function and quality of life. In residency, he gained much experience in musculoskeletal medicine, rehabilitation, spine, and sports medicine along with some regenerative medicine. He also gained significant experience in fluoroscopically guided spinal procedures and peripheral injections. However, Dr. Pitts wanted to broaden his skills and treatment options beyond the current typical standards of care.

Read more

Jason Markle, D.O.

Post-residency, Dr. Markle was selected to the Interventional Orthopedic Fellowship program at the Centeno-Schultz Clinic. During his fellowship, he gained significant experience in the new field of Interventional Orthopedics and regenerative medicine, honing his skills in advanced injection techniques into the spine and joints treating patients with autologous, bone marrow concentrate and platelet solutions. Dr. Markle then accepted a full-time attending physician position at the Centeno-Schultz Clinic, where he both treats patients and trains Interventional Orthopedics fellows. Dr. Markle is an active member of the Interventional Orthopedic Foundation and serves as a course instructor, where he trains physicians from around the world.

Read more

Matthew William Hyzy, D.O.

Doctor Hyzy is Board Certified in Physical Medicine and Rehabilitation (Physiatry) and fellowship-trained in Interventional Orthopedics and Spine. Dr. Hyzy is also clinical faculty at the University of Colorado School of Medicine in the Department of Physical Medicine and Rehabilitation; In addition, Dr. Hyzy is an Adjunct Clinical Assistant Professor at The Rocky Vista University College of Osteopathic Medicine. Dr. Hyzy also maintains an active hospital-based practice at Swedish Medical Center and Sky Ridge Medical Center. He is also recognized and qualified as an expert physician witness for medical-legal cases and Life Care Planning. He is published in the use of autologous solutions including…

Read more

Brandon T. Money, D.O., M.S.

Dr. Money is an Indiana native who now proudly calls Colorado home. He attended medical school at Kansas City University and then returned to Indiana to complete a Physical Medicine and Rehabilitation residency program at Indiana University, where he was trained on non-surgical methods to improve health and function as well as rehabilitative care following trauma, stroke, spinal cord injury, brain injury, etc. Dr. Money has been following the ideology behind Centeno-Schultz Clinic and Regenexx since he was in medical school, as he believed there had to be a better way to care for patients than the status quo. The human body has incredible healing capabilities…

Read more
Mairin Jerome, MD

Mairin Jerome, MD

Dr. Mairin Jerome is a physiatrist with subspecialty fellowship training in Interventional Orthopedics and Regenerative Medicine. This subspecialty serves to fill the gap for patients who are interested in therapeutic options that lie between conservative treatment and surgery. Dr. Jerome uses regenerative medicine techniques, including prolotherapy and orthobiologics, via X-ray or ultrasound guidance to precisely deliver injections to areas of musculoskeletal injury or degeneration. Orthobiologics refers to tissue harvested typically from a person’s own body, such as platelets (platelet-rich plasma, PRP) or bone marrow, for use in treating painful musculoskeletal conditions. The goal is to stimulate the body’s healing mechanisms to improve pain, function, and decrease inflammation.

Read more

————

(1) Waterman BR, Belmont PJ, Schoenfeld AJ. Low back pain in the United States: incidence and risk factors for presentation in the emergency setting. Spine J. 2012;12(1):63-70.DOI: 10.1016/j.spinee.2011.09.002

(2) Chopra P, Tinkle B, Hamonet C, et al. Pain management in the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. 2017;175(1):212-9.DOI: 10.1002/ajmg.c.31554

(3) Zhou Z, Rewari A, Shanthanna H. Management of chronic pain in Ehlers-Danlos syndrome: Two case reports and a review of literature. Medicine (Baltimore). 2018;97(45):e13115.doi: 10.1097/MD.0000000000013115

(4) Tewari S, Madabushi R, Agarwal A, Gautam SK, Khuba S. Chronic pain in a patient with Ehlers-Danlos syndrome (hypermobility type): The role of myofascial trigger point injections. J Bodyw Mov Ther. 2017;21(1):194-6.DOI: 10.1016/j.jbmt.2016.06.017

(5) Laseter JT, Russell JA. Anabolic steroid-induced tendon pathology: a review of the literature. Med Sci Sports Exerc.1991;23(1):1-3.

(6) Singla V, Batra YK, Bharti N, Goni VG, Marwaha N. Steroid vs. Platelet-Rich Plasma in Ultrasound-Guided Sacroiliac Joint Injection for Chronic Low Back Pain. Pain Pract. 2017;17(6):782-91.DOI: 10.1111/papr.12526

(7) Ko GD, Mindra S, Lawson GE, Whitmore S, Arseneau L. Case series of ultrasound-guided platelet-rich plasma injections for sacroiliac joint dysfunction. J Back Musculoskelet Rehabil. 2017;30(2):363-70.DOI: 10.3233/BMR-160734

FREE eBook Download (Click the Book Cover)

Ready to get help for your EDS Back Pain?

Get Help