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Craniocervical Instability

A New Nonsurgical Regnerative Treatment Option: The “PICL”

In 2015 a nonsurgical treatment option for Cranial Cervical Instability was developed at the Centeno-Schultz Clinic.  It involves the injection of a patient’s own bone marrow concentrate which contains stem cells into the damaged Alar and Transverse ligaments.  The procedure is very demanding and only performed at the Centeno-Schultz Clinic in Broomfield Colorado. The procedure is called Percutaneous Implantation of Cervical Ligaments (PICL)  To learn more about this groundbreaking procedure please click on the video below.

Meet AW: Another PICL Success Story

AW is a 29 y/o athletic Denver travel agent who presented with a 5-year history of neck pain and neurologic symptoms.  Her past medical history was significant for hypermobility and chronic fatigue.  Her neck pain was constant involving her entire neck with radiations into her head with debilitating headaches.  Her neurologic symptoms included brain fog, headaches, nausea, dizziness and heavy head and difficulty swallowing.  Onset of symptoms was not associated with trauma. Physical therapy, rest, medications, acupuncture, heat, ice, stretching, chiropractic failed to provide any relief.  AW was evaluated by multiple physicians without a clear diagnosis.  Focus was placed on treating symptoms as opposed to understandin the underlying problem. Her history together, physical examination and abnormal Digital Motion X-ray confirmed the diagnosis of craniocervical instability.  She declined fusion surgery and proceeded with two PICL procedures where bone marrow concentrate containing stem cells was injected directly into the damaged cervical ligaments.  Her response has been dramatic.  AW summarizes her journey and results from the PICL procedures best:

“It’s been 5 years since I had to change careers and take a desk job, and 4 years since I was housebound due to my then diagnosis of Chronic Fatigue Syndrome. Before finally finding Dr. Schultz, I had seen 27 specialists and doctors, none of whom had any idea how to help a previously strong and healthy 25 year-old who went from playing club volleyball at CU Boulder and hiking daily to having to be carried to her home office from bed everyday. To say it’s been a long and painful road is an unbelievable understatement, but after being accurately diagnosed by Dr. Shcultz with CCI in Feb 2021 and treated with two PICL procedures, I am now recovering and living life again, rather than managing my symptoms. Not only am I able to walk to my desk and work a full day, I was able to take long walks on the sandy beaches in Hawaii last week, fly to Hawaii in the first place, snorkel for hours, and just went on my first hike in more than 5 years in Steamboat this weekend. I can’t even begin to describe how incredibly thankful I am for Dr Schultz and his team, the procedure, and for the many now possible adventures to come. “


It was all a blur.  The headaches, brain fog and fatigue started gradually and got worse.  Simple tasks became overwhelming.  Isolation and functional limitation ensued.  Physical therapy, chiropractic care, medications and rest failed to help.  Physicians were not certain as to the cause of my symptoms.  Many were dismissive and suggested that it was an emotional or pyschological issue.  Your chiropractor thought the problem was in your neck.  What is Craniocervical Instability (CCI)? What are the eight most common symptoms of CCI? How is CCI Diagnosed? What are the treatment options for Cranio-cervical Instability? What is Craniocervical Instability Surgery? What non-surgical treatment options exist? Meet AW.  Let’s dig in. 

What Is Craniocervical Instability? What Causes It? 

Cranial Cervical Instability (CCI) is a medical condition where the strong ligaments that hold your head to your upper neck are loose or lax (1). The major ligaments involved are the Alar, Transverse and Accessory ligaments.   To learn more about CCI please click on the video below.

What Are the 6 Most Common Symptoms of Craniocervical Instability?

Excessive movement between your head and neck can irritation and damage of the upper cervical facet joints, discs, nerves, and blood vessels.  Symptoms vary depending upon the amount of instability.  The most common symptoms include:

1. Painful, Heavy Head

A constant to near-constant head pain can be described as feeling like the head is too heavy for the neck to support.  Many describe feeling like they have a “bobblehead”. Neck weakness along with ligament instability results in head forward posture in many patients.  This has significant consequences as the weight of your head dramatically increases as it moves forward from neutral alignment.  This is illustrated below.  On the left, in neutral spinal alignment, your head weighs 12 lbs. With just 2 inches forward posture the weight of the head increases to 32lbs.  Add another 1 inch forward and the weight increases to 42lbs.  This is an enormous amount of weight that can not be sustained or supported.  Often times the result is chronically tight trap muscles as they are now tasked with supporting this heavy head. 

2. Headache

This is not your normal headache caused by your in-laws or excessive consumption of alcohol.  This is a debilitating headache that is constant in duration and miserable.  The headache may be localized at the base of the skull (suboccipital) or radiate from the upper neck into the forehead and eyes in a ram’s horn distribution. 

3. Brain Fog brain fog? that can help your doctor in Diagnosing Craniocervical Instability

Patients with CCI  can struggle with memory, concentration, and ability to complete tasks. Every day can feel like your brain is stuffed full of cotton.  Executive function can be severely compromised making employment or studying nearly impossible.  

4. Rapid Heart Rate

Elevated heart rate may occur as the vagus nerve gets irritated by the extra motion in the upper neck.  Another cause of elevated heart rate is Postural Orthostatic Tachycardia Syndrome (POTS).  POTS is a medical condition that causes malfunction of the autonomic nervous system. It is estimated to impact between 1,000,000 and 3,000,000 Americans.  The autonomic nervous system controls involuntary body functions such as heart rate and blood pressure.  Malfunction of the autonomic nervous system causes several symptoms which include rapid heart rate.

5. Neck Pain

Neck pain is typically localized at the base of the skull and aggravated with flexion,rotation and lateral side bending.  The pain be localized or radiate up into the base of the skull causing a headache.  The pain can also radiate down into the lower neck and shoulders causing trapezius and scapular pain.  Neck pain can be sharp and stabbing, dull and aching or throbbing. 

6. Visual Problems

Visual disturbances can vary from mild to severe involving a number of symptoms.  Visual disturbances can happen because the upper neck supplies information to the brain to guide eye position and vice versa (2).

How Is Cervical Instability Diagnosed?  7 Main Criteria

At the Centeno-Schultz Clinic, we are committed to understanding and identifying the underlying cause of your pain and dysfunction. For that a correct diagnosis must be made.   Treating symptoms is helpful but does not provide for the best clinical outcome.  CCI is poorly understood and oftentimes missed.  Diagnosing CCI involves 7 main criteria which include:

1. Mechanism of Injury (How Did It Occur)

Understanding how and when the injury occurred is important.  The two most common causes of Cranial Cervical Instability (CCI) are trauma and medical conditions that cause people to have loose or compromised ligaments (2). Motor vehicle accidents, contact sports, and forceful manipulations by chiropractors are the most common examples of trauma.  Ehlers Danlos Syndrome (EDS) is a group of inherited disorders that affect your ligaments and connective tissues (2).

2.Symptoms

The symptoms associated with CCI can be extensive depending upon the severity of the instability.  The most common symptoms were described above. 

Arm Pain at Night

Arm pain at night can be miserable.  The pain can interrupt your sleep and erode your quality of life. Irritability becomes increasingly more common.  What are the causes?  When should I worry about it?  What are the treatment options for arm pain at night? The neck is composed of 7 boney building blocks numbered 1- 7. Sandwiched between the bones is a disc that functions as an important shock absorber. The cervical discs are susceptible to injury due to trauma, degeneration, repetitive motion, and surgery. Common disc injuries include disc bulges, and herniations. The injured disc can compress or irritate one or more nerves resulting in arm pain at night. It can…

Read More About Arm Pain at Night

Brain Fog

Brain fog is one of the hallmark symptoms of Craniocervical instability. It is characterized by slow thinking, difficulty focusing, confusion, lack of concentration, forgetfulness, or haziness in thought. The severity of symptoms varies from patient to patient. Ever had a bad hangover or high fever and had trouble concentrating or completing simple tasks? This brain fog. Some patients describe it as a generalized haziness in thought as if cotton were stuck in the head. In addition to cognitive impairments, many patients also report generalized mental fatigue making complex tasks almost impossible. The exact cause of brain fog is unknown. Possible explanations include…

Read More About Brain Fog

Cervicalgia / Neck Pain

Cervicalgia is also known as neck pain, which is an all-too-common, unpleasant pain. Read here to learn the symptoms, diagnosis, and treatment options. We will discuss other causes for cervicalgia. What symptoms are associated with cervicalgia? How is cervicalgia diagnosed? What are the treatment options for cervicalgia? Cervicalgia is a medical term used to describe neck pain. It is very common and affects approximately 2/3 of the population at some point in their life. Cervicalgia is the 4th major cause of disability. Risk factors include injury, prior history of neck and musculoskeletal pain, jobs that require a lot of desk work, low social support, job insecurity, physical weakness, and poor computer station setup.

Read More About Cervicalgia / Neck Pain

Chronic Fatigue

Have you ever had a challenging all-day hike, athletic endeavor, or worked a double shift and felt exhausted the next day? Later that day or the next morning, moving across the room may have seemed almost impossible and took herculean power. Now image this occurs on a daily basis without any provocation. 24/7 simple tasks are nearly impossible due to a lack of strength and energy. This is chronic fatigue, and it is one of the common symptoms associated with craniocervical instability. Severity can vary and in severe cases, patients are confined to their beds. Aggravating and alleviating factors often times can not be identified.

Read More About Chronic Fatigue

Chronic Headaches

Do you suffer from chronic headaches? Maybe it’s a daily issue, maybe once a week, maybe even less often, but one thing’s for sure—when a chronic headache kicks in, it can be a real pain in the neck, literally. In order to effectively address chronic headaches, you have to first determine if the pain is caused by a problem in your neck. Let’s take a look at a few neck issues that can cause headaches: Weak neck muscles – The head, on average, weighs about ten pounds, so when the neck muscles are weak, it can make your head feel a bit like a bowling ball that your neck can’t quite balance. There are many muscles that, along with the cervical spine, work together to help support the neck and aid movement…

Read More About Chronic Headaches

Gastrointestinal (GI) Problems

Gastrointestinal (GI) problems can be debilitating comprising one’s wellbeing and ability to confidently engage in life. Symptoms vary and can include nausea, bloating, constipation, diarrhea, delayed motility, abdominal pain, irritable bowel-like symptoms, heartburn, and reflux. GI problems can be due to structural and functional problems within the gut itself. Examples include hiatal hernia and bacterial overgrowth. Less appreciated is the fact that many patients with Craniocervical instability (CCI) can also have significant GI problems. Regrettably, many of these patients undergo extensive, costly GI evaluations only are told that their examinations and studies are normal. This can be extremely frustrating. For these patients…

Read More About Gastrointestinal (GI) Problems

Jugular Vein Compression

The internal jugular vein is a major vein in the neck that carries deoxygenated blood from the head and face back to the heart. Due to its location, it is susceptible to compression from various structures in the neck, including muscles, bones, and ligaments.One of the main causes of jugular vein compression is thought to be craniocervical instability (CCI), a condition caused by the misalignment of the upper neck bones C1 and C2 that can lead to symptoms such as dizziness, headaches, poor balance, fatigue, tinnitus, and more. The following is an in-depth examination of jugular vein compression symptoms, how it is caused…

Read More About Jugular Vein Compression

Muscle Pain After Cervical Fusion Surgery

Cervical Fusion is a major surgery that involves joining one or more of the spinal bones together using screws, bolts, and plates (1). The hardware may be placed in the front (anterior) or the back( posterior) of the cervical spine. The disc between the spinal bones is often times removed and replaced with a bone graft or a spacer. The neck of composed of 7 boney building blocks that are numbered from 1-7. The letter C is associated with the numbers to designate the cervical spine. Hence the bones in the neck are C1 through C7. Sandwiched between neck bones are important shock absorbers called discs. A cervical fusion surgery removes…

Read More About Muscle Pain After Cervical Fusion Surgery

Neck Pain And Dizziness

Our body’s balancing system is compromised of three separate systems that work closely together to keep the body in balance: the eyes, inner ear, and upper cervical spine. The upper cervical spine contains and processes information about your position in space and communicates this information to your eyes and inner ears via nerves. There is a constant highway of electrical signals between the cervical spine, inner ear, and eyes that keep us upright, make us aware of our position and enable us to walk, move and run. This balancing system requires the inner ear, eyes and cervical spine to be operational…

Read More About Neck Pain And Dizziness

Pain At The Base Of The Neck And Skull

The base of the skull is a complex area.  It involves the upper cervical spine, facet joints, muscles, tendons, ligaments, and nerves.  Irritation or injury to any one of these structures can result in pain at the base of the skull.  Unfortunately, this area is not understood by many providers.  This can lead to a delay in treatment and unnecessary pain and suffering.Treatment options depend upon the underlying cause of the pain.  Conservative therapy in the form of physical therapy when appropriate is the best first-line treatment.  Steroids are often recommended but should be avoided as they are toxic to orthopedic tissue and have significant side effects…

Read More About Pain At The Base Of The Neck And Skull

Pain In The Left Side Of The Neck 

Understanding the causes of left-sided neck pain is crucial for proper diagnosis and treatment. Left-sided neck pain can result from several factors, including musculoskeletal issues, nerve compression, trauma, inflammation, or underlying medical conditions.  Muscular strains, poor posture, and stress are common causes of neck pain. Additionally, conditions such as cervical disc herniation, cervical spinal stenosis, and osteoarthritis can lead to left-sided neck pain. According to global estimates, neck pain affects a significant portion of the population. In the United States alone, it has been reported that about 10% to 15% of individuals experience neck pain at any given time. Neck pain can occur in people of all ages, although it tends to be more prevalent in adults.

Read More About Pain In The Left Side Of The Neck 

Rapid Heart Rate

Rapid heart rate can be debilitating, compromising your wellbeing and ability to complete the easiest of tasks, and, unfortunately, it is a common symptom of craniocervical instability or other upper cervical conditions. Normal resting adult heart rate ranges from 60-85 beats per minute. Tachycardia is a medical term for heart rates of 100 beats per minute. Most of us have experienced rapid heart rates after vigorous exertion or exercise. Remember how your heart was rapidly beating after wind sprints or chasing after your dog who jumped the fence? Your heart is rapidly pounding in your chest. Unfortunately for some patients that is their baseline.

Read More About Rapid Heart Rate

Stiff Neck

Conventional wisdom states that stiff neck symptoms can be treatable with nonsurgical remedies. However, not all stiff neck symptoms are benign, and leaving the stiff neck untreated can lead to a limited range of motion that can affect your overall health and quality of life. A stiff neck can cause pain, tightness, popping, and clicking noises and sensations and affect daily activities. A detailed examination of stiff neck symptoms can determine the exact condition affecting the stiffness of one’s neck. Where does the neck hurt? Neck stiffness can occur at the base of the head, down to the shoulders. This can be associated with pain, crunching noises, or popping sensations and may…

Read More About Stiff Neck

Tinnitus

Remember the ringing in your ears after a loud rock concert or highly charged sporting event? It is that ringing or buzzing sound that slowly improves the next day over several hours.  Unfortunately for some individuals, the ringing in the ears is not due to an external event.  Even worse is it does not resolve over time.  This condition is called tinnitus.   It is a medical condition characterized by ringing or other noises in one or both ears NOT caused by an external sound.   Other individuals cannot hear the ringing that patients describe. It is a common problem.  It affects approximately 15-20% of individuals. 

Read More About Tinnitus
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3.Physical Examination

In the age of managed care and 15-minute appointments, the art and practice of physical examination by a physician is almost gone.  At the Centeno -Schultz Clinic all new patient evaluations undergo an extensive physical examination. Why? It is important to view the body as a whole and there are multiple potential physical findings in the neck, head, shoulder, and low back in patients with Cranial Cervical Instability,

4. Radiographic Studies

There are various types of radiographic studies which include x-ray, CT scan, and  MRI.  Unfortunately, traditional MRI and CT studies do not evaluate the upper cervical spine or Alar and Transverse ligaments. Special radiographic studies are required which include upper cervical MRI or rotatory CT scan.  In addition, there are additional studies that involve the patient moving during the examination.  These  dynamic studies are useful to identify instability.  Examples include upright MRI with upright flexion/extension.  To see how this works please click on the video below.

Finally, a Digital Motion X-ray (DMX) study is important in establishing the diagnosis of CCI.  This is an x-ray examination that is recorded in which the patient is put through various movements including bending the neck forward, backward, and to the side.  To learn more about DMX please click on the video below.

5. Response to Conservative Care

The common symptoms of CCI can also arise from different clinical conditions. For example, headaches with dizziness may arise from tight or contracted neck muscles.  It is important that patients undergo conservative care such as rest, heat, stretching, physical therapy, massage, and chiropractic care.  In some cases, symptoms improve with conservative therapy.

6. Response to Diagnostic Injections

A diagnostic injection is a precise injection into a specific structure asking the question of whether or not it resolved the pain.  Often times this is very helpful in the evaluation of patients with CCI. All diagnostic injections are performed under ultrasound or x-ray or both.  Examples of diagnostic injections include cervical facets, occipital nerve blocks and ligament injections.

7. Level of Disability

In many cases due to the severity of the symptoms patients are not able to complete their domestic or professional responsibilities.  In severe cases of CCI, patients are confined to their homes and are socially isolated. The level of disability is important in diagnosing Craniocervical Instability (CCI).

Craniocervical Instability Treatment Options: Conservative Care, Injections and Surgery

Treatment of Craniocervical Instability is challenging.  Not having an accurate diagnosis can make it even more challenging.  A lack of diagnosis can send patients on a many-year journey looking for assistance.  Some will be dismissed as their complaints are considered not valid or genuine whereas others will be labeled “hormonal”, anxious or psychiatric and referred elsewhere or medicated with anti-depressants, opioids, or anti-anxiety medications.  There are three major types of CCI treatments: conservative care, injections and Craniocervical Instability Surgery.  The specific type of treatment will depend upon the amount of instability and a patient’s clinical presentation.

Cervical Fusion

Cervical Fusion is often recommended when chronic neck pain problems worsen over time. What exactly is it? Cervical Fusion is a major surgery that involves joining one or more of the spinal bones together using screws, bolts, and plates (1). The hardware may be placed in the front (anterior) or the back( posterior) of the Cervical spine. The disc between the spinal bones is often times removed and replaced with a bone graft or a spacer. The neck of composed of 7 boney building blocks that are numbered from 1-7. The letter C is associated with the numbers to designate the Cervical Spine.

Read More About Cervical Fusion

NSAIDs

The other day I was evaluating a patient and reviewing the treatment options for their spine condition.  After discussing prior treatments, we got to the topic of medications taken for pain relief. She explained that she mainly utilized anti-inflammatory (NSAID) medications and then she told me to hold much she takes and has been for many years…..she takes close to 2 grams (2000 milligrams) on a daily basis which equated to about 9-10 capsules of medication per day.  I was shocked, considering she was pre-diabetic and with high blood pressure plus the kicker of it is that her PCP (primary care physician) is ok with this…

Read More About NSAIDs

Occipital Cervical Fusion

An Occipital Cervical Fusion also known as Occipitocervical Susion is a Major Surgery. It is not a routine operation and is a challenging procedure due to complex anatomy of the upper neck. The procedure involves rods, plates and screws that are placed into the Cervical Spine and Occiput. A plate secured by screws are placed at the base of the Occiput. Screws are also placed into one or more Cervical bones. Rods then connect the Occipital plate to the Cervical screws as shown below. The goal of Occipital Cervical Surgery is a boney fusion between the skull and neck and to relieve…

Read More About Occipital Cervical Fusion

PICL Procedure

CCI stands for cranial cervical instability which means that the ligaments that hold the head on are too loose. To help that problem, we developed a new procedure called PICL which stands for Percutaneous Implantation of the CCJ Ligaments. This is still an investigational procedure that has already changed many lives and helped patients avoid a complication-laden upper cervical fusion. Given the interest in the PICL procedure from patients who have CCI, there are lots of questions. Since the procedure isn’t yet covered by insurance, a few have asked why it costs more than their co-pay and deductible if they decide to have a more invasive cervical fusion.

Read More About PICL Procedure

PRP Injections

PRP is short for platelet-rich plasma, and it is autologous blood with concentrations of platelets above baseline values. The potential benefit of platelet-rich plasma has received considerable interest due to the appeal of a simple, safe, and minimally invasive method of applying growth factors. PRP treatments are a form of regenerative medicine that utilizes the blood healing factors to help the body repair itself by means of injecting PRP into the damaged tissue. In regenerative orthopedics, it is typically used for the treatment of muscle strains, tears, ligament and tendon tears, minor arthritis, and joint instability. There have been more than 30 randomized controlled trials of PRP…

Read More About PRP Injections

Conservative Care

Patients with small amounts of instability can oftentimes be managed with conservative care.  Treatment options include:

1. Upper cervical chiropractic care.  Look for members of NUCCA (National Upper Cervical Chiropractic Association)
2. Physical Therapy
3. Bracing
4. Curve restoration. Look for chiropractors that specialize:  Chiropractic BioPhysics or CBP is a protocol utilized by a select group of chiropractors who look to spinal rehabilitation and postural correction as a means to address pain, disease, and dysfunction.

Precise Injections

Greater and Lesser Occipital Nerves

Precise x-ray guided injections with PRP or bone marrow concentrate which contains stem cells are the next treatment options for those patients who fail to receive any clinical benefit from conservative care. Examples include

  • C0/1 and C1/2 facet injections.  A facet is a paired joint on the backside of the spine that provides support and limits rotation of the spine.  It can also be irritated or injured causing significant neck and head pain (3).   Few clinics perform this injection due to the skill required.
  • Occipitals Nerve block.  The Occipital nerves arise from the upper cervical spine and travel up into the back of the head.  There is one nerve on each side of the head.  When irritated, injured, or compressed they can cause significant pain in the back and top of the head (4).
  • Superficial Cervical Plexus injection
  • Ligament injections to stabilize injured or lax ligaments.  Ligaments are thick pieces of connective tissue that connect bone to bone.  Loose or damaged ligaments can cause significant instability, pain, and dysfunction.

Surgical Treatment & Their Complications

Craniocervical Instability Surgery always involves a fusion.  Fusion is a surgical procedure where one or more of the bones in the spine are joined together by screws, bolts, and rods.  The hardware provides mechanical stability. In most cases of Craniocervical Instability, the upper portion of the neck (C1 and C2 vertebral bodies)  is fused to the skull.  The skull is also called the occiput.  The surgery can also be called an Occipitocervical Fusion.  This is major surgery and rehabilitation.  The procedure depending upon the complexity typically ranges from 130-320 minutes (9).

The upper cervical spine is a very complex area rich in nerves, arteries, veins, ligaments, tendons, and muscles.  The risks  associated with upper neck fusion are significant and include (9):

craniocervical instability surgery
Upper Neck Fusion Screw Loosening: White Arrow

Screw failure

The screw that is inserted into the occiput or C1 or C2 can fracture, bend or break.  In most cases surgical revision is necessary.

Screw loosening

The implanted screw can back out of the bone over time compromising the stability of the upper neck.

Infection

The infection can be localized to the skin or may penetrate deeper into the muscles or bone.  Antibiotics are oftentimes required for skin infections.  Bone infections require additional surgery.

Vertebral Artery injury

The Vertebral Artery provides critical blood flow to the spinal cord and brain.  The artery can be compressed, irritated, or injured during the surgery.

Spinal Cord Injury

The spinal cord runs from the base of the head to the lower back and contains critical nerve tissue that controls the central nervous system.

Cervical Facet Injury

The screw can be advanced into the facet joint thereby injuring the joint cartilage leading to arthritis, pain, and restriction in range of motion.

Upper Neck Muscle Weakness

The muscles can be injured during surgical fusion.

Dural Leak

The Dura is a thin layer of connective tissue that covers the brain and spinal cord.  It can be injured during the surgery resulting in leakage of spinal fluid (10).

Hematoma

A collection of blood that can compress or injure nerves, arteries, and veins

Persistent upper cervical instability requiring additional surgery .(11)

Limited Neck Range of Motion

Fusion of the skull base to the upper neck can severely restrict the range of motion in the upper neck.

Adjacent Segment Disease (ASD)

Fusion of the spine significantly alters the biomechanics of the spine.  The fused segment is no longer able to absorb the forces of daily living.  As such these forces are then transferred above and below the fusion.  This additional force can overload the discs, facet joints, muscle, and ligaments above and below the fusion which start to break down.  To learn more about Adjacent Segment Disease please click on the video below.

In Conclusion

  • Craniocervical Instability is a medical condition characterized by injury and instability of the ligaments that hold your head onto the neck.
  • Common symptoms of Cranial Cervical Instability include a painful, heavy head, headache, rapid heart rate, brain fog, neck pain, visual problems, dizziness, and chronic fatigue.
  • CCI or neck ligament laxity treatment options depend upon the severity of the instability and clinical symptoms. When appropriate, conservative care should always be the first-line treatment.
  • Craniocervical Instability Surgery is often recommended when conservative care fails. This involves a fusion of the head to the neck which is a major surgery that is associated with significant risks and complications.
  • The PICL procedure is a revolutionary non-surgical Craniocervical Instability treatment option where a patient’s own stem cells are injected into the damaged upper cervical ligaments.
  • AW successfully avoided CCI surgery by having her stem cells injected into her damaged Alar and Transverse ligaments at the Centeno-Schultz Clinic.

If you or a loved one has sustained an injury with ongoing headaches, neck pain, and brain fog please schedule a telephone candidacy discussion with a board-certified, fellowship-trained physician.  From the comfort of your home or office learn what treatment options are available for you. Call today and stop the pain, misery, and suffering.

*Not all patients can achieve these great results, but we’re continuing to improve patient selection and procedural techniques. 

Related Conditions

Cervical Medullary Syndrome

Cervical Medullary Syndrome is a clinical condition that occurs as a result of inflammation, deformity, or compression of the lower part of the brain. Symptoms can be extensive with fluctuating severity based upon the extent of the underlying injury. For example, mild irritation of the brainstem may cause only mild, intermittent symptoms. The upper cervical spine and brain are complex with multiple structures.  These structures reside within the skull and protective confines of the cervical spine.  Neither expands to accommodate inflammation, injury, and disease.  Rather the delicate tissues of the brain and spinal cord are irritated or compressed.   The 4 major conditions that cause cervical medullary syndrome are… 

Read More About Cervical Medullary Syndrome

Chiari Malformation

Chiari Malformation Is a medical condition where a part of the brain at the back of the skull abnormally descends through an opening in the skull. It is named after Dr. Hans Chiari who was an Austrian pathologist who in the late 1880’s studied deformities of the brain.The brain is a large structure divided into different parts that reside within the skull. Important parts of the brain called the Cerebellum and Brainstem sit at the base of the skull. The Foramen Magnum is a large hole at the base of the skull that allows the brain to join the spinal canal. The Cerebellum…

Read More About Chiari Malformation

Atlantoaxial Instability (AAI)

Instability simply means that bones move around too much, usually due to damaged ligaments. In the spine, this can cause nerves to get banged into and joints to get damaged. In the craniocervical junction, instability can cause the upper cervical spinal nerves to get irritated, leading to headaches. In addition, the C0-C1 and C1-C2 facet joints can also get damaged. In addition, there are other nerves that exit the skull here that can get irritated, like the vagus nerve, which can cause rapid heart rate. What’s the Difference Between CCI and AAI? CCI refers to instability in any part of the craniocervical junction…

Read More About Atlantoaxial Instability (AAI)

Ehlers-Danlos Syndrome (EDS)

Disorders that affect and weaken the connective tissues such as tendons and ligaments. It is a hereditary disorder which means you are born with it.  EDS has many different signs and symptoms which can vary significantly depending upon the type of EDS and its severity.   It most commonly affects the skin, joints, and blood vessels.  Joints are typically hypermobile with excessive joint range of motion because of a defect in collagen formation. In most cases Ehlers-Danlos syndrome is inherited. That is to say that you are born with it. The two main ways EDS is inherited are: autosomal dominant inheritance and autosomal recessive inheritance…

Read More About Ehlers-Danlos Syndrome (EDS)
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Our Doctors Who Treat Craniocervical Instability

Christopher J. Centeno, MD

Christopher J. Centeno, M.D. is an international expert and specialist in Interventional Orthopedics and the clinical use of bone marrow concentrate in orthopedics. He is board-certified in physical medicine and rehabilitation with a subspecialty of pain medicine through The American Board of Physical Medicine and Rehabilitation. Dr. Centeno is one of the few physicians in the world with extensive experience in the culture expansion of and clinical use of adult bone marrow concentrate to treat orthopedic injuries. His clinic incorporates a variety of revolutionary pain management techniques to bring its broad patient base relief and results. Dr. Centeno treats patients from all over the US who…

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John Schultz, MD

John R. Schultz M.D. is a national expert and specialist in Interventional Orthopedics and the clinical use of bone marrow concentrate for orthopedic injuries. He is board certified in Anesthesiology and Pain Medicine and underwent fellowship training in both. Dr. Schultz has extensive experience with same day as well as culture expanded bone marrow concentrate and sees patients at the CSC Broomfield, Colorado Clinic, as well the Regenexx Clinic in Grand Cayman. Dr. Schultz emphasis is on the evaluation and treatment of thoracic and cervical disc, facet, nerve, and ligament injuries including the non-surgical treatment of Craniocervical instability (CCI). Dr. Schultz trained at George Washington School of…

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Other Resources

  • What Is Intracranial Hypertension And How Is It Connected To The Neck?

    Nowadays, more and more people are dealing with neck pain and headaches. There are a lot of different causes of neck pain and headaches, one of which is intracranial hypertension. Anyone diagnosed with intracranial hypertension will want to know more about it. For example, you might wonder why it causes headaches or if the condition…


  • What Is the Alar Ligament?

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